MTHFR – No It’s not a Swear Word – But It’s VERY serious

One of the new ‘buzzwords’ in the healthy industry is Methylation or more accurately known as Methyltetrahydrofolate Reductase. I’d not even heard of this medical term until a few months ago, as many of the mums in the Autism community were talking about them discovering that their child was recently found to not ‘methylate’ – and this now made them see clearly, why their child was not able to process the chemicals in their vaccines or from also absorbing toxins inside their womb during pregnancy.

Methylation is a very process in the body that enables the body to process heavy metals and toxins.

If you don’t methylate very well, then you are more than likely to suffer with toxin related health problems.  Methylation is more than just detoxing, it also helps a huge array of functions.

I discovered the following information about Methylation from Dr Amy Yaskos website:

Why is the Methylation Cycle Important?

The Methylation Cycle is a biochemical pathway that manages or contributes to a wide range of crucial bodily functions, including:

  • Detoxification
  • Immune function
  • Maintaining DNA
  • Energy production
  • Mood balancing
  • Controlling inflammation

All these processes help the body respond to environmental stressors, to detoxify, and to adapt and rebuild. That’s why lowered methylation function may contribute to many, major chronic conditions, including:

  • Cardiovascular Disease
  • Cancer
  • Diabetes
  • Adult neurological conditions
  • Autism and other spectrum disorders
  • Chronic Fatigue Syndrome
  • Alzheimer’s disease
  • Miscarriages, fertility, and problems in pregnancy
  • Allergies, immune system, and digestive problems
  • Mood and psychiatric disorders
  • Aging

Methylation is involved in almost every bodily biochemical reaction, and occurs billions of times every second in our cells. That’s why figuring out where the Cycle can better  perform its tasks contributes to health improvement, and reduce symptoms.

Please check out Dr Amy’s website its fantastic

What are the symptoms with MTHFR gene defects? 

Three symptom areas:
    1.  Central Nervous System disorders – some of these come from Homocysteine not getting converted into SAMe.  SAMe is responsible for creating Serotonin, Dopamine, and Norepinephrine (neurotransmitters responsible for mood, motivation, and to some degree energy levels – if these are low, then Depression is often the result, but even aggression and alcoholism are symptoms sometimes found in men).  Pregnant women may encounter extreme Post-partum depression.  Also, things like Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS (Irritable Bowel Syndrome), Memory loss with Alzheimer’s and Dementia and other psychiatric problems can be tied to this issue (OCD, Bipolar, Schizophrenia, and more).  These challenges are typically more related to the 1298 gene mutation.  A very recent clinical trial (not even published yet) was done by Dr. Fava (July, 2011) showed that giving L-Methylfolate (Metafolin) found in the prescription ‘medical food’, Deplin, was as effective as the top anti-depressant drugs available today (and without all the side effects).

 2.  Cardiovascular problems often occur when Homocysteine levels in the body are too high.  Heart attack, Stroke, Blood clotsPeripheral neuropathy, Anemia even Miscarriages and Congenital birth defects can be related to this issue among others.  These problems are typically more related to the 677 gene mutation, but the worst is for a person who has one 677 variant and one 1298 variant.

 3.  Environmental poisoning can increase when not enough Homocysteine gets converted into Glutathione.  Glutathione is responsible for detoxifying the body of the heavy metals we encounter in the environment – it is our body’s most powerful antioxidant.  When a body gets too burdened by heavy metals and toxins, a lot of unexpected health problems emerge.  Some symptoms of this can be: nausea, diarrhea, abdominal pain, liver and kidney dysfunction, hypertension, tachycardia, pulmonary fibrosis, asthma, immune problems, hair loss, rashes and more.

Sometimes diseases/disorders fall under a ‘two-pronged’ cause, meaning the causes of it stem from both genetic and environmental problems).  Autism is a big one that falls into this ‘two-pronged’ cause category [American Journal of Biochemistry and Biotechnology, 2008] along with FibromyalgiaChronic Fatigue Syndrome and more.  MTHFR is at the top of a list of 16 genetic defects for autism.  Another study showed 98% of children with autism had one or both of the MTHFR gene defects (677 and/or 1298).  A recent clinical study indicated that mothers with MTHFR who didn’t take folate during pregnancy were 7 times more likely to have an autistic child than mothers without the MTHFR gene defect [Epidemiology, July 2011, Vol. 22, Issue 4, pgs 476-485].  Colon and gastric cancers also have key links to the MTHFR gene defects, just do an internet search on ‘MTHFR and colon cancer’ or ‘MTHFR and gastric cancer’ and you will find many clinical studies and articles on the subject.

Above information from

For further Information please watch the youtube clip above the top of this post. Below is a description about what it covers

Dr. Neil Rawlins gives an insightful 51-minute lecture on MTHFR (Methyltetrahydrofolate Reductase) in September of 2011. In it he covers what MTHFR is, what the symptoms of MTHFR are, as well as how to treat it and some of the products available to do so. He also covers some clinical trial information as well. He is incredibly informative on the topic as he has been studying it in earnest for over 5 years now. The near death of his son propelled him to embark on a personal journey to learn all about MTHFR and treat it in his family. Dr. Rawlins has treated hundreds of patients with great success.

please click here  to download a PDF that will help you use diet to improve Methylation process.